Tenosynovial Giant Cell Tumor (TGCT), also known as Pigmented Villonodular Synovitis (PVNS), is a rare tumor that develops from the lining of the joints and surrounding structures. Symptoms include:

  • joint pain
  • tenderness
  • locking or popping of the joint
  • swelling
  • limited range of motion
  • buildup of joint fluid

These symptoms can range in severity and potentially result in disability.

There are two types of tumors typically found with TGCT:

Localized TGCTs are the most common and the most amenable to surgery, and can cause painful swelling in small joints. They most often impact people ages 30 to 50.

Diffuse TGCTs are less common and can be more difficult to treat. Tumors are typically found in large joints like knees or hips. They are more likely to recur even after removal by surgery. Diffuse TGCTs typically occur in patients under age 40.

Learn how the MOTION study aims to advance TGCT / PVNS research.